#NULLIFY27 · July 12–14, 2027 · Singapore
Global Summit on Vaccine Durability, Waning Immunity & Next-Generation Protection

WHEN
VACCINES
DON'T LAST

The world's first dedicated summit on vaccine efficacy limitations, waning immunity, and the science of immunological durability. Three days. One question: how do we build protection that holds?

Register Now → Sponsor NULLIFY 2027 Vaccine Durability Conference Guide
Event Details
NULLIFY 2027
Singapore
📅
Dates
July 12–14, 2027
🔧
Pre-Conference Workshops
July 11, 2027
📍
Venue
Hilton Singapore Orchard
🎯
Format
In-Person + Live-Streamed Hybrid
👥
Capacity
300 in-person · 500 virtual
Registration Open · Early-bird pricing ends 2 October 2026. Secure your delegate pass at the reduced rate.
Countdown to NULLIFY 2027 Conference opens July 12, 2027 · Singapore
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Registration open Save up to 43% Early-bird registration ends October 2, 2026 Register now →

The Scientific Imperative

Post-COVID immunology exposed a critical gap.
NULLIFY 2027 addresses it directly.

38%
Average efficacy drop in mRNA vaccines after six months, documented across multiple real-world effectiveness studies post-approval.
$12B
Global R&D investment currently targeting vaccine durability challenges, yet no dedicated scientific forum exists to accelerate convergence.
4.2B
People globally affected by booster schedule uncertainty, with recommendations set without the immunological benchmarks to support them.
60+
Biomedical companies with Asia-Pacific headquarters in Singapore, making it the strategic centre of gravity for global vaccine R&D.

We know how to generate an immune response. We do not yet know how to make it last. NULLIFY 2027 is the first forum dedicated entirely to that gap and what to do about it.

"Booster schedules are being set without the immunological benchmarks to support them. Regulators and public health agencies need clearer correlates of protection. This summit builds them."

Waning Immunity Science, B-cell memory, antibody kinetics, and T-cell longevity all converge on the same unanswered question: what determines whether protection persists or fades?

Next-Gen Formulation, Adjuvants, delivery systems, antigen design, and mucosal immunity strategies are all targeting durability. R&D teams need a dedicated space to share, challenge, and accelerate.

Global Equity Gap, Cold chain limitations, population immunosenescence, and comorbidity burdens mean waning immunity is not a universal curve. LMICs face a different efficacy crisis than wealthy nations.

Who Attends

The Scientists, Regulators, Industry Leaders & Policymakers Whose Work Converges Here

NULLIFY 2027 brings together the scientific, regulatory, commercial, and policy stakeholders whose work converges on vaccine durability, many for the first time in the same room.

🔬
Immunologists & Vaccinologists
Scientists studying antibody kinetics, memory B-cells, correlates of protection, and immunosenescence. University research departments, NIH, Wellcome Trust, CEPI-funded labs.
🧬
Pharma & Biotech R&D
R&D teams working on next-generation vaccines, adjuvant systems, antigen optimisation, and novel delivery platforms. mRNA developers, formulation scientists, clinical leads.
📋
Regulators & Public Health
FDA, EMA, WHO representatives, national immunisation programme leads, GAVI and CEPI coalition partners, and health technology assessment bodies.
💼
Clinical Development Leads
Regulatory affairs directors, principal investigators, CRO and CDMO leaders responsible for translating durability science into approvable product profiles.
💹
Life Sciences Investors
VCs, corporate venture arms, and strategic investors evaluating the commercial landscape in vaccine durability, booster platforms, and adjuvant innovation.
🌍
Global Health & Policy
WHO Collaborating Centres, GAVI, CEPI, Coalition partners, and LMIC programme leads navigating thermostability, cold chain, and population-specific waning profiles.
📊
Epidemiologists & Data Scientists
Scientists building real-world effectiveness models, waning immunity curves, and booster timing algorithms from national surveillance and cohort data.
🏛️
Health Economics & HTA
Health economists modelling cost-per-QALY of booster strategies, durability thresholds, and population-level immunisation investment cases.

Why They Attend NULLIFY 2027

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Cross-sector convergence: scientists, regulators, pharma, and policymakers in one room for three days

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Data-first agenda: presentations based on real-world efficacy studies, clinical data, and mechanistic science

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Actionable outputs: the conference produces a published research agenda and policy recommendations

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Singapore location: Asia-Pacific hub minimises travel for 60%+ of global vaccine R&D professionals

Scientific Programme

Three Days. Three Lenses. One Mission.

Each day is structured around a distinct lens on the efficacy durability problem from molecular mechanisms through engineering solutions to global health policy and the research agenda the field needs.

Day 1 · July 12, 2027
The Biology of Waning
  • Antibody kinetics post-vaccination: what the decay curves tell us
  • Memory B-cell longevity and the germinal centre response
  • T-cell exhaustion and its role in breakthrough infections
  • Immunosenescence: why the elderly lose protection first
  • Mucosal vs systemic immunity: durability trade-offs
  • Keynote: Correlates of protection, do we finally know what to measure?
  • Panel: Interpreting real-world efficacy data across variant waves
Day 2 · July 13, 2027
Engineering Durability
  • Next-generation adjuvants: beyond AS01 and MF59
  • Antigen design for breadth and longevity
  • Self-amplifying RNA: does it change the persistence equation?
  • Nanoparticle delivery: lymph node targeting and depot effects
  • Intranasal and mucosal vaccine platforms
  • Heterologous prime-boost: mixing platforms for durability
  • Panel: When does a booster make sense, and when is it failure?
Day 3 · July 14, 2027
Policy, Equity & Future
  • Booster policy frameworks: evidence thresholds for recommendations
  • Regulatory pathways for durability claims: EMA, FDA, WHO
  • LMIC immunisation programmes: different waning, different solutions
  • Cold chain constraints and thermostable formulation
  • Health economics of durability: cost per QALY of boosting
  • The 10-year vaccine: what would it take?
  • Closing Keynote: The research agenda NULLIFY 2027 recommends
Pre-Conference Workshops · July 11, 2027
Four half-day deep-dive workshops · Capped at 40 delegates each · $250 per workshop
Workshop A
Measuring Waning Immunity
Statistical approaches and study design
Workshop B
Adjuvant Formulation for Durability
Formulation science masterclass
Workshop C
Regulatory Submissions for Booster Indications
EMA/FDA guidance on durability claims
Workshop D
LMIC Vaccine Deployment
Cold chain, thermostability, population waning

Faculty & Speakers

World-Class Scientific Faculty

Confirmed Speakers

Immunology · Academia
Vaccinology · Global Health
Regulatory Science · Industry
Adjuvant Research · Biotech
Clinical Vaccinology · WHO

60+ speakers will be announced across keynotes, plenaries, panel sessions, and workshop leads. We are actively recruiting faculty from academia, pharma, regulatory agencies, and global health organisations.

🔬 Immunologists 🏥 Clinical Vaccinologists 📋 Regulators (FDA/EMA/WHO) 🧬 R&D Scientists 🌍 Global Health Leaders 💼 Industry Executives

Get notified when speakers are announced. Be the first to hear about confirmed faculty and programme updates.

Subscribe for Updates →

Confirmed Venue

Hilton Singapore Orchard

NULLIFY 2027 will convene the vaccine durability community in the heart of Singapore's Orchard Road district, with dedicated conference, meeting, and hospitality spaces for three days of scientific and commercial exchange.

Venue Confirmed

Meet at Hilton Singapore Orchard.

The hotel provides a central, professional setting for plenary sessions, scientific discussion, private meetings, and delegate networking. Accommodation and arrival guidance will be shared with registered attendees.

Address
333 Orchard Road
Singapore 238867
Dates
July 12–14, 2027
Format
In-person + virtual access
Open in Google Maps
Theatre-style seating in the Grand Ballroom at Hilton Singapore Orchard
Grand Ballroom • Hilton Singapore Orchard
Cluster seating configuration in the Grand Ballroom at Hilton Singapore Orchard
Flexible conference configurations
Ficus boardroom at Hilton Singapore Orchard
Executive meeting spaces
Chef preparing hospitality service at Hilton Singapore Orchard
Elevated delegate hospitality
Global Access
A central Singapore location for international scientific, clinical, regulatory, and industry delegates.
Life Sciences Capital
Singapore connects regional biomedical leadership with global vaccine research and commercialization networks.
Orchard Road Setting
A landmark central district with convenient access to transport, hospitality, dining, and business infrastructure.

Get In Touch

Contact NULLIFY 2027

Whether you're interested in sponsoring, speaking, attending, or have a general enquiry, our team will respond within 2 business days.

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Direct Contact

✉️
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July 12–14, 2027 · Singapore

Join us in Singapore for NULLIFY 2027

Early-bird registration closes 2 October 2026. Sponsorship slots are limited and confirmed on a first-come, first-served basis.

Register Now → Sponsor NULLIFY 2027

#NULLIFY27 · www.nullify2027.com · akhil.sravan@synerg.events · © 2026 NULLIFY 2027. All rights reserved.

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NULLIFY 2027 · Singapore · July 12–14, 2027
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